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Presentation and Diagnosis of PBC

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with PBC? What are the most and least common symptoms of the disease?

What is the typical path to a diagnosis for patients with PBC?

What clinical and laboratory assessments do you perform, and what markers do you look for?

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Video Series

Expanding Treatment Options for Primary Biliary Cholangitis with Novel Therapies

Primary biliary cholangitis (PBC) often presents with fatigue and pruritus as the most common symptoms, while jaundice and xanthomas are less frequent. The diagnostic pathway typically involves a combination of clinical evaluation, laboratory tests, and imaging studies. Key laboratory assessments include elevated alkaline phosphatase levels and the presence of antimitochondrial antibodies (AMA). Liver biopsy may be performed to confirm diagnosis and assess disease stage. Imaging, such as ultrasound or MRI, helps rule out other liver conditions. Early diagnosis is crucial for effective management and improved patient outcomes.

The panelists discuss the typical presentation of primary biliary cholangitis (PBC), covering common and uncommon symptoms, the diagnostic journey, and key clinical and laboratory assessments used to identify disease markers.