Mardi Gomberg-Maitland, MD, MSc, is the director of the pulmonary hypertension program, chief clinical research officer at the Office of Clinical Research SMHS, and a professor of medicine at George Washington University.

CADENCE: Sotatercept Reduces PVR in CpcPH-HFpEF, With Mardi Gomberg-Maitland, MD, MSc

Sotatercept has reduced pulmonary vascular resistance (PVR) in combined post- and pre-capillary pulmonary hypertension (CpcPH) 

heart failure with preserved ejection fraction (HFpEF)

, improving both pulmonary vascular and cardiac end points, according to data from the CADENCE trial.

American College of Cardiology (ACC) Scientific Sessions 2026

 in New Orleans, Louisiana, by Mardi Gomberg-Maitland, MD, MSc, director of the pulmonary hypertension program, chief clinical research officer at the Office of Clinical Research SMHS, and professor of medicine at George Washington University.

“Here we have a drug for a disease that we’ve never had therapy for, one that has high morbidity and mortality, and now we have potential,” Gomberg-Maitland told 

 in an exclusive interview. “We’re seeing good effects – now it’s time that we move to the next phase, to phase 3.”

CADENCE is an ongoing phase 2, multicenter, double-blind, randomized trial investigating the efficacy, safety, and tolerability of sotatercept in patients with CpcPH-HFpEF. The trial consisted of a 24-week placebo-controlled treatment period and an active-drug extension period. Gomberg-Maitland and colleagues reported the placebo-controlled period, during which patients were randomly assigned in a 1:1:1 ratio to receive subcutaneous sotatercept at 0.3 mg/kg (before potential escalation to 0.7 mg/kg after 3 dosing visits) or placebo every 3 weeks.

Eligible patients were aged 18-85 years with symptomatic CpcPH-HFpEF diagnosed via an assessment of hemodynamics through right heart catheterization. Patients were excluded if they were diagnosed with another form of pulmonary hypertension, clinically significant lung disease, severe hepatic impairment, and/or cirrhosis, among other criteria.

CADENCE’s primary efficacy endpoint was the change from baseline in PVR at week 24. The key secondary efficacy endpoint was the change from baseline in 6-meter walk distance at week 24. Other secondary endpoints included time to clinical worsening, which was defined as the time from the first dose date to the first occurrence of all-cause death or non-elective hospitalization for cardiopulmonary indications related to pulmonary hypertension and/or heart failure, and change from baseline in N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, NYHA functional class, and hemodynamic or echocardiographic parameters.

A total of 164 patients were randomized, with 54 assigned to sotatercept 0.3 mg/kg, 55 assigned to 0.7 mg/kg escalated from 0.3, and 55 assigned to placebo. The median duration of follow-up during this period was 5.6 months (interquartile range [IQR], 5.5-5.7) in the 0.3 mg/kg group, 5.6 months (IQR, 5.5-5.8) in the 0.7 mg/kg group, and 5.6 months (IQR, 5.5-5.8) in the placebo group.

By week 24, sotatercept treatment resulted in substantially greater reductions in PVR versus placebo. The median change from baseline was -0.67 Wood units in the 0.3 mg/kg group, -0.33 Wood units in the 0.7 mg/kg group, and 0.26 Wood units in the placebo group. The Hodges-Lehmann shift estimate was -1.02 Wood units (95% CI, -1.81 to -0.23; 

 = .004) for the 0.3 mg/kg group and -0.75 Wood units (95% CI, -1.52 to 0.03; 

 = .024) for the 0.7 mg/kg group compared to placebo. These results were consistent across subgroups, including the degree of PVR elevation at baseline.

Mean pulmonary arterial pressure saw a mean reduction of -9.19 mmHg (95% CI, -13 to -5.38) and -9.22 (95% CI, -12.97 to -5.46) in the 0.3 mg/kg and 0.7 mg/kg groups, respectively. Changes in 6-minute walk distance were 20.3 meters (95% CI, 1.5 to 39.1) for the 0.3 mg/kg group and 5.8 meters (95% CI, -17.3 to 28.9) for the 0.7 mg/kg group.

Ultimately, Gomberg-Maitland and colleagues noted that these findings provide an effective proof of concept for improved pulmonary vascular and cardiac hemodynamics following activin signaling inhibition with sotatercept in patients with CpcPH-HFpEF.

“As for how it can impact therapy, we’re going to continue into our phase 3 trials to really look at these echo parameters over time and see if this is perhaps a way that we can follow patients,” Gomberg said. “Ultimately, you don’t want to be doing right heart casts on everybody to see how they’re doing. We need other assessments that are more functional.”

Editors’ Note: Gomberg-Maitland reports disclosures with Merck, Catalys Pacific, Gossamer, Janssen Pharmaceuticals, Medtronic, Novartis, and others.

Gomberg-Maitland M, Tedford R, Langleben D, et al. Efficacy and Safety of Sotatercept in Combined Post- and Pre-capillary Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction: results from the Phase 2 Cadence Trial. Abstract presented at the American College of Cardiology Scientific Sessions 2026, New Orleans, Louisiana. March 28-30, 2026.

Gomberg-Maitland M, Tedford RJ, Langleben D, et al. Sotatercept for combined post- and pre-capillary pulmonary hypertension associated with heart failure: Results from the phase 2, randomized, placebo-controlled Cadence Study. 

Videos

Gomberg-Maitland addresses sotatercept’s capacity to improve pulmonary vascular and cardiac endpoints in patients with CpcPH-HFpEF.

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Sayna Norouzi, MD, is an assistant professor of medicine and clinical nephrologist at Loma Linda University Medical Center

New Therapeutic Options Raise More Questions for IgA Nephropathy Treatment, With Sayna Norouzi, MD

Evidence shows a continually and rapidly expanding therapeutic landscape for patients with IgA nephropathy (IgAN). Due to the heterogeneity of the disease, clinicians remain undecided about how to approach these options with the IgAN’s complex, individualized presentation.

“It's getting more and more complicated with having more options out there, and we still have ongoing clinical trials, and we recruit for these trials as well. We have to keep in mind that we don't have a cure for IgAN yet, and we're not done with this field,” Norouzi siad. “I think the next step for a lot of our colleagues who are not spending a lot of time with IgAN patients would be a referral to a glomerular disease clinic or center of excellence.”

At WCN, a plethora of data supporting positive progress in IgAN was presented. In a

, Norouzi highlighted the emergence of targeted agents, including targeted-release budesonide, endothelin receptor antagonists like sparsentan and atrasentan, complement inhibitors such as iptacopan, and newer APRIL-targeting therapies. Together, these agents provide clinicians with multiple avenues to reduce proteinuria and preserve kidney function.

“When I go back from every conference that I attend to my clinic, my patients are excited. Sometimes I share with them that I'm going to a conference, and they know when I come back, I'm going to have more data, and they might have more options for their disease. And it's not just about IgAN. We're getting more options for C3G, lupus nephritis,” she concluded. “It's an exciting time to be a nephrologist.”

Norouzi reports relevant disclosures with Calliditas, Travere, Apellis and others.

Norouzi discussed the remaining challenges that come with having evolving treatment options and a robust patient population in IgAN.

Nephrology

The HCPLive nephrology page is a resource for medical news and expert insights on kidney disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in nephrology, and more.

IgA Nephropathy

The HCPLive Berger disease page is a resource for medical news and expert insights on IgA nephropathy. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments in Berger disease, and more.

Ryan Livingston joined the MJH Life Sciences team in March of 2025, shortly after graduating from TCNJ with a bachelor’s degree in English. He enjoys creative writing, reading, and scuba diving. He can be reached at rlivingston@mjhlifesciences.com.

 ushered in a new wave of groundbreaking research into 

, and more. With hundreds of experts presenting hundreds of new studies and analyses, every aspect of cardiology received its fair share of updates.

With such a deluge of information, updates, and trial results, the 

 editorial team has collected 5 of the most impactful Phase 2 and 3 trials that should be on every clinician’s radar. Catch up on the biggest news from ACC.26 below:


Tonlamarsen Lowers Angiotensinogen, Mixed Results for Blood Pressure, With Luke Laffin, MD


KARDINAL was a randomized, placebo-controlled phase 2 trial of tonlamarsen in patients with uncontrolled hypertension, aiming to evaluate its efficacy in reducing plasma angiotensinogen and blood pressure. Presented by Luke Laffin, MD, co-director of the Center for Blood Pressure Disorders at Cleveland Clinic, these data showed a substantially greater percentage reduction in angiotensinogen among patients receiving monthly doses, with a least-squares mean percent change of -67.2%. However, tonlamarsen displayed no meaningful difference in blood pressure reduction between monthly doses and a single dose followed by placebo.


SCOUT-HCM: Mavacamten Outperforms Placebo in Adolescents With HCM, With Joseph Rossano, MD, MS


The SCOUT-HCM phase 3 trial is still ongoing, but at ACC.26, Joseph Rossano, MD, MS, co-director of the Cardiac Center at the Children’s Hospital of Philadelphia, presented data on mavacamten’s efficacy in reducing left ventricular outflow in adolescents with 

obstructive hypertrophic cardiomyopathy (HCM)

 compared to placebo. The analysis included 44 patients; of these, the 23 assigned to receive mavacamten saw dramatic reductions in mean Valsalva left ventricular outflow tract gradient compared to placebo recipients.


Evolocumab Reduces CV Risk in Non-Atherosclerotic Patients With Diabetes, With Nicholas Marston, MD, MPH


This secondary analysis of the VESALIUS-CV trial, presented by Nicholas Marston, MD, MPH, a preventive cardiologist at Brigham and Women’s Hospital, highlighted oral PCSK9 inhibitor evolocumab’s capacity to lower 

 in high-risk patients without a history of major cardiovascular events and with diabetes. A composite endpoint including coronary heart disease death, myocardial infarction, or ischemic stroke – as well as a 4-part endpoint including ischemia-driven arterial revascularization – occurred far less among patients treated with evolocumab compared to those receiving placebo.


MOMENTUM: Hypercortisolism Present in 1-in-4 with Resistant Hypertension


Presented by Deepak Bhatt, MD, MPH, MBA, director of Mount Sinai Fuster Heart Hospital, the MOMENTUM trial revealed that the prevalence of endogenous hypercortisolism may be significantly higher among patients with resistant hypertension than previously thought. Investigators identified the condition in more than 1 in 4 patients of the 1086 screened, evaluating each patient via a 1-mg overnight dexamethasone suppression test. Bhatt and colleagues hope the results will support increased screening for hypercortisolism moving forward.


CHAMPION-AF: Left Atrial Appendage Closure Noninferior to NOACs


Device-based left atrial appendage closure was noninferior to non-vitamin K antagonist oral anticoagulant therapy (NOAC) for preventing adverse events in patients with atrial fibrillation, according to data from the CHAMPION-AF trial. Presented by Saibal Kar, MD, program director of the cardiovascular disease fellowship at Los Robles Regional Medical Center in California, this trial enrolled 3000 patients with non-valvular atrial fibrillation, assigning them to either the Watchman Fix device or an approved NOAC. At 3 years, a composite endpoint of cardiovascular death, stroke, or systemic embolism occurred in 81 patients in the device group and 65 in the NOAC group, while non-procedure-related bleeding occurred in 10.9% of the device group and 19% of NOAC patients.

Catch up on the most impactful trial readouts to come out of ACC 2026.

Arrhythmia

Cardiomyopathy

Hypertension

The HCPLive hypertension page is a resource for medical news and expert insights on high blood pressure. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for hypertension, and more.

Dyslipidemia

ACC 2026: Phase 2/3 Trials to Know

Tim Smith joined the MJH Life Sciences team in 2022 and is currently an associate editor for HCPLive. He is also the executive producer of two podcasts: Skin of Color Savvy and The Medical Sisterhood. Previously, he was the producer of the Lungcast podcast. He graduated from UC Berkeley and worked in multimedia journalism as a staff writer prior to joining MJH. You can contact him at tsmith@mjhlifesciences.com.

 as a disease state commanded a notable share of the late-breaking data presented at the 

2026 American Academy of Dermatology (AAD) Annual Meeting

 in Denver, Colorado, with research spanning a broad and rapidly evolving therapeutic landscape, from established biologics accumulating long-term comparative and extension data to emerging oral medications designed to meaningfully shift how psoriasis is managed in the years to come.

Several themes ran through much of the psoriasis program, including the growing momentum behind oral targeted treatments and the continued push to validate sustained skin clearance well beyond the 16-week primary endpoints known to have historically defined the field. Nail psoriasis and generalized pustular psoriasis (GPP) also featured in the data released at the meeting, reflecting a broader effort to address the full clinical spectrum of psoriatic disease. The following 6 updates from AAD represent key trials clinicians managing psoriasis should know:

ONWARD: Oral Envudeucitinib Demonstrates High PASI Responses in Phase 3, With Andrew Blauvelt, MD

One set of trials from AAD was ONWARD1 and 2, highlighting new phase 3 data for envudeucitinib. This drug, a next-generation, highly selective oral TYK2 inhibitor, demonstrating robust skin clearance in moderate-to-severe plaque psoriasis, was discussed by Andrew Blauvelt, MD, MBA, owner of Blauvelt Consulting, LLC, and principal investigator on the ONWARD program. Both ONWARD1 and ONWARD2 together enrolled more than 1700 adult patients living with moderate-to-severe plaque psoriasis.

Sustained PASI Responses Observed Through Week 60 with Zasocitinib, With Melinda Gooderham, MD

The LATITUDE trial program, highlighted during the AAD late-breaking data sessions, suggests zasocitinib could help to reshape the oral treatment landscape for moderate-to-severe plaque psoriasis. The drug was shown to have a high level of skin clearance, a result typically seen with biologics. Melinda Gooderham, MD, medical director of the SKiN Centre for Dermatology in Ontario, Canada, spoke about these key findings from the pair of pivotal phase 3 studies evaluating zasocitinib against both placebo and an active comparator, apremilast.

Risankizumab Outperforms Deucravacitinib on Psoriasis Clearance Across Patient Subgroups in Phase 4 Head-to-Head Trial

Risankizumab was another drug with new data presented during AAD, with findings demonstrating significantly greater skin clearance than deucravacitinib at the 16-week mark across an array of patient subgroups among adults with biologic-naïve moderate plaque psoriasis. These new data resulted from a subgroup analysis of the phase 4 IMMpactful trial, with the findings highlighting subgroup populations defined by race, sex, age, smoking status, baseline disease severity, body mass index (BMI), and presence of psoriatic arthritis (PsA).

ICONIC-LEAD: 1 Year Icotrokinra Data Confirm Durable Psoriasis Clearance, PRO Improvements in Adults, Adolescents, With Jennifer Soung, MD

Icotrokinra was another drug spotlighted during AAD, with 1-year data from the phase 3 ICONIC-LEAD trial confirming icotrokinra delivered durable skin clearance and meaningful patient-reported improvements among adults and adolescents with moderate-to-severe plaque psoriasis. ICONIC-LEAD investigators also identified no new safety signals through the 52-week mark. This medication became the first and only targeted oral peptide blocking the interleukin (IL)-23 receptor after being approved by the United States Food and Drug Administration (FDA) on March 18, 2026, for psoriasis.

Tildrakizumab Sustains Nail Psoriasis Efficacy Through 52 Weeks in Phase 3b Extension Data

New 52-week results also released during AAD showcased a phase 3b trial of tildrakizumab treatment of moderate-to-severe nail psoriasis, with these data demonstrating continued improvement in the level of nail clearance and sustained response seen among early responders, extending results first reported at last year’s AAD. Thia analysis is the first dedicated phase 3b trial of an IL-23 inhibitor in nail psoriasis.

EFFISAYIL ON: New Long-Term Data Released on Spesolimab Injection for GPP

Results from an ongoing open-label extension analysis were released by LEO Pharma at AAD regarding spesolimab-sbzo in adults with GPP. The EFFISAYIL ON analysis is an open-label extension trial lasting 5 years, designed to examine the long-term efficacy, safety, and tolerability of subcutaneous (SC) spesolimab in those who had previously partaken in either the EFFISAYIL 1 or EFFISAYIL 2 pivotal trials. These findings provide encouraging data suggesting this biologic agent can meaningfully diminish patients’ GPP flare burden over several years of treatment.

Articles

Late-breaking psoriasis data from AAD 2026 underscored a broad maturation of the therapeutic landscape, particularly the acceleration of oral targeted agents approaching biologic-like efficacy and the field’s pivot toward durability beyond traditional 16-week endpoints. Across plaque psoriasis programs, multiple late-stage datasets emphasized sustained PASI responses through 52–60 weeks with favorable safety continuity. Additional updates expanded evidence for harder-to-treat phenotypes, including dedicated nail psoriasis phase 3b extension outcomes and multi-year flare-burden reduction in generalized pustular psoriasis using subcutaneous biologic therapy.

This review of new data on psoriasis treatments from AAD 2026 highlights several key trials.

Plaque Psoriasis

The HCPLive plaque psoriasis page is a resource for medical news and expert insights on psoriasis. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for psoriatic disease, and more.

Dermatology

The HCPLive dermatology page is a resource for medical news and expert insights on skin disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for dermatologic conditions, and more.

AAD 2026: 6 Psoriasis Trials to Know

Alex Hillenbrand is an assistant editor for 

. She earned her BA in English from Lafayette College in 2023 and went on to write for pop culture, entertainment, and sports media outlets before joining MJH Life Sciences in 2025. In her free time, Alex enjoys cooking, going on walks, and meeting new people. Contact her at mjhlifesciences.com.

March encompassed a number of key updates in the nephrology landscape, including revised clinical practice guidelines from Kidney Disease: Improving Global Outcomes (KDIGO), phase 3 clinical trial data on emerging therapies for 

, and featured content examining the International Society of Glomerular Disease (ISGD)'s latest research advances alongside a deep dive into how neighborhood disadvantage drives kidney disease risk and progression.

In this edition, KDIGO announces a focused update to its 2024 CKD guideline, spotlighting newer pharmacologic agents in the management of CKD progression, including the nonsteroidal mineralocorticoid receptor antagonist finerenone, which has now demonstrated statistically significant eGFR slope improvement in nondiabetic CKD populations in the phase 3 FIND-CKD trial. In IgAN, povetacicept achieved a 52% reduction in urine protein-to-creatinine ratio (UPCR) versus baseline in the RAINIER trial's 36-week interim analysis, reinforcing the therapeutic potential of BAFF/APRIL dual inhibition.

 examines the intersection of social determinants of health and CKD risk, specifically how neighborhood disadvantage may drive disease burden in ways that biomarkers alone cannot capture, alongside a special report from the International Society of Glomerular Disease (ISGD) on the transformative scientific advances reshaping our biological understanding of glomerulonephritis and related conditions over the past five years.

KDIGO Launches Focused Update to 2024 CKD Guideline on Emerging Therapies

KDIGO announced a formal update to the 2024 Clinical Practice Guideline for the Evaluation and Management of CKD, one of the most widely used global resources for CKD evaluation and management. The update will focus on Chapter 3, "Delaying CKD progression and managing its complications," with particular emphasis on medical management using newer therapies in light of the evolving therapeutic landscape.

Finerenone Proves CKD Benefit Extends Beyond Diabetes in FIND-CKD

Bayer announced the phase 3 FIND-CKD trial evaluating finerenone (Kerendia) in adult patients with nondiabetic CKD met its primary endpoint, demonstrating a statistically significant improvement in eGFR slope versus placebo over 32 months. The company indicated it planned to submit the data to the US Food and Drug Administration (FDA) to seek a label expansion into this patient population, which would represent the broadest application of the agent to date across a CKD program spanning more than 20,000 patients in phase 3 trials.

RAINIER: Povetacicept Reduces Proteinuria By 52.0%

Povetacicept met its primary and secondary endpoints in RAINIER, an ongoing phase 3 trial evaluating adults with IgA nephropathy (IgAN), according to a 36-week interim analysis. Vertex Pharmaceuticals announced positive results where povetacicept showed a 52.0% reduction in urine protein to creatinine ratio (UPCR) compared to baseline, with a statistically significant and clinically meaningful 49.8% UPCR reduction compared to placebo (

Crisis Point: The Cause and Calamity, Neighborhood Disadvantage and Kidney Disease

Clinicians often thought of healthcare as having a problem and a solution, but this Crisis Point examined what was going on underneath the surface. With the rising threat of chronic kidney disease, more was at stake than the values measurable in a lab, this piece focused on the detrimental problem of neighborhood disadvantage as both the cause and the calamity of kidney disease.

ISGD and the Fastest 5 Years in Glomerular Disease

For experts from ISGD, the last 5 years were the fastest and most dynamic period in glomerular disease. In this special report, Barbara Gillespie, MD, an adult nephrologist at the University of North Carolina and Chief Medical and Strategy Officer at ISGD, and Toby Huber, MD, head of Internal Medicine at Hamburg-Eppendorf in Germany and founding president of ISGD, broke down the scientific advances and how they revolutionized biological understanding of glomerular diseases.

March highlights underscored rapid evolution in CKD and glomerular disease management, spanning guideline refinement, late-stage trial readouts, and broader risk frameworks. A focused KDIGO update targets Chapter 3 recommendations on delaying CKD progression, emphasizing integration of newer agents. Finerenone expanded its evidence base with statistically significant eGFR slope benefit in nondiabetic CKD in FIND-CKD, supporting a planned FDA label-expansion effort. In IgAN, BAFF/APRIL dual inhibition with povetacicept produced marked proteinuria reductions in interim phase 3 data. Social and biologic drivers of kidney disease were also foregrounded.

Catch up on the guideline updates, trial news, and featured content from March 2026. 


Chronic Kidney Disease

5 Nephrology Headlines You Missed in March 2026

Diana Isaacs, PharmD, is an endocrine clinical pharmacist, director of Education and Training in Diabetes Technology, and codirector of Endocrine Disorders in Pregnancy at the Cleveland Clinic.

Podcasts

This episode discusses the recently released algorithm for T2D from the American Association of Clinical Endocrinology.

Type 2 Diabetes

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podcasts page features a feed of medical news and interview podcast series, including DocTalk, Lungcast, Derm Discussions, and Heart Trials.

Diabetes Dialogue: 2026 AACE Guidelines for Type 2 Diabetes

Victoria Johnson joined MJH Life Sciences in 2020 and has written for NeurologyLive, CGTLive, and is now an assistant managing editor for HCPLive and RheumatologyLive. She doesn’t have enough time for her numerous hobbies. You can reach her at vjohnson@mjhlifesciences.com.

Check out 6 FDA decisions to watch in Q2 2026, listed chronologically by expected decision date.

Pulmonology

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Q2 2026 Preview: 6 FDA Decisions to Watch

Luke Laffin, MD, is the co-director of the Center for Blood Pressure Disorders, medical director of cardiac rehabilitation, and associate professor of medicine at Cleveland Clinic.

Laffin discusses results from the Kardinal study, which investigated a single dose of tonlamarsen followed by placebo against monthly tonlamarsen treatment in hypertension.

Eingun James Song, MD, is the director of clinical research for Frontier Dermatology. 

In this AAD interview, Song highlights how he views the potential benefit of amlitelimab in light of discontinuing rocatinlimab.

Atopic Dermatitis

Atopic Dermatitis condition center page, audiences can find a variety of coverage mediums for medical news and updates, including articles, video interviews, podcasts, and breaking news on dermatitis research, treatment, and drug development.

Discussing Future of Amlitelimab, OX40/OX40L Treatment, With Eingun James Song, MD

Read 6 updates from the meeting that clinicians managing atopic dermatitis should know.

AAD 2026: 6 Atopic Dermatitis Trials to Know

Future directions in ISM, including evolving treatment goals, unanswered questions about osteoporosis, anaphylaxis, resistance, curative strategies, and the need to extend advances to pediatric populations.

Video Series

Future Directions in ISM: Long-term Outcomes, Unanswered Questions, and Pediatric Considerations

Explore evolving colorectal cancer screening, from colonoscopy to advanced DNA/RNA stool tests, plus risk-based strategies and shared decisions that boost early detection.

Key Takeaways in Colorectal Cancer Screening

Positive FIT/Cologuard? See why follow-up colonoscopy is often $0 and how navigation, rides, and time-off support boost screening.

Coordinating Care After Abnormal Colorectal Cancer Results

Michael E. Thase, MD, of the University of Pennsylvania

In part 3 of an interview, Michael E. Thase, MD, discusses retreatment timing, safety monitoring, and research priorities following phase 2b GH001 data.

Psychiatry

Psychiatry condition center page is a comprehensive resource for clinical news and insights on mental illnesses. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for depression, schizophrenia, bipolar disorder, anxiety, and more.

Major Depressive Disorder

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Maintenance Dosing, Safety Shape GH001 Outlook, With Michael E. Thase, MD

Use of symptom and quality-of-life tools alongside biomarkers in PIONEER, principles of dose titration from 25 mg to 50 mg, and practical recommendations for longitudinal safety monitoring.

Latest News

CADENCE: Sotatercept Reduces PVR in CpcPH-HFpEF, With Mardi Gomberg-Maitland, MD, MSc

New Therapeutic Options Raise More Questions for IgA Nephropathy Treatment, With Sayna Norouzi, MD

ACC 2026: Phase 2/3 Trials to Know

AAD 2026: 6 Psoriasis Trials to Know

5 Nephrology Headlines You Missed in March 2026