Waldman Professor of Dermatology and Immunology, health system chair of the Kimberly and Eric J. Waldman Department of Dermatology, and director of the Laboratory for Inflammatory Skin Diseases at the Icahn School of Medicine at Mount Sina

 report inadequately controlled disease despite current biologics targeting type 2 inflammation.

 Oral JAK inhibitors act on broader pathways but carry a boxed warning many patients and dermatologists prefer to avoid. Rezpegaldesleukin is an IL-2 receptor agonist designed to selectively expand regulatory T cells (Tregs) rather than block a single cytokine axis.

In the phase 2b REZOLVE-AD trial (NCT06136741), rezpegaldesleukin 24 μg/kg every 2 weeks produced statistically significant improvements across primary and secondary endpoints after a 16-week induction phase compared with placebo.

 A biomarker sub-study presented as a late-breaking oral at EADV Congress 2026 analyzed 100 patients, 59 on rezpegaldesleukin and 41 on placebo. Blood and lesional tape strips were collected at baseline and at weeks 2 and 4 and evaluated by RNA-seq and Olink proteomics.

By week 2, rezpegaldesleukin significantly upregulated Treg and T-cell activation markers, including ICOS, CD3D/E, CTLA4, FOXP3, IL2RA, and IL2RB, versus both baseline and placebo.

<.0001) each predicted week 16 EASI exclusively in the rezpegaldesleukin arm, with no comparable correlations in the placebo arm (all |R|≤0.30, 

Rezpegaldesleukin also reduced fibrosis-associated transcripts, including POSTN, COL15A1, ELN, COL16A1, COL1A1, and LUM, alongside markers across the Th1, Th2, Th17, and Th22 axes (all P<0.05).

 Clinically, the mean EASI reduction reached 64.3% at week 16, with 42.4% of patients achieving EASI75 and significant separation from placebo as early as week 2 across EASI-50/75/90, IGA 0/1, and itch outcomes.

Emma Guttman-Yassky, MD, PhD, Waldman Professor of Dermatology and Immunology at the Icahn School of Medicine at Mount Sinai, led the biomarker sub-study. In the following interview, Guttman-Yassky discusses how rezpegaldesleukin's regulatory T-cell mechanism differs from existing AD therapies and what the earliest molecular changes revealed.

HCPLive: Despite biologics and JAK inhibitors, why do so many AD patients still have uncontrolled disease?

Atopic dermatitis is a heterogeneous disease, and while we have good treatments now, they either target one pathway, like the Th2 pathway, or they're oral JAK inhibitors that act on more pathways. The issue with oral medications, particularly JAK inhibitors, is the black box warning, so many dermatologists and many patients don't want to go there. When we give patients Th2-targeting biologics, we will miss some patients because of the heterogeneity of the disease.

HCPLive: IL-2 can stimulate both regulatory and effector T cells. How is this molecule designed to favor Tregs?

It's all about the dosing. The dosing is key here. We did the biomarker study, and interestingly, the biomarkers showed even greater differentiation from placebo, because typically, when you look at the skin, it tells you things earlier than the clinical results, and we saw things much, much earlier. In fact, even at week 2 we saw meaningful data, and based on week 2 biomarkers, we could predict week 16 responses.

HCPLive: Can you expand on what the skin showed at the molecular level within the first 2 weeks?

We saw significant modulation of many markers, including Th2 markers. We also saw increases in some Treg markers, and some of these, such as CCL17 and Treg markers like TGF-beta and IL-10, were significantly correlated with the clinical improvement at week 16.

[Fibrosis-associated markers also fell, which] matters because in atopic dermatitis you have hyperplasia, and hyperplasia involves some fibrosis. We also know fibroblasts can produce inflammatory markers and are important. In general, we believe fibrosis is important in atopic dermatitis and in other diseases, so we're excited about the potential of this drug for other indications.

HCPLive: Blood markers at week 2 tracked with EASI at week 16. Do you see potential there for predicting response?

Yes, we think that's a very nice feature that we sometimes see, where early responses can predict later responses, and I can see how this could shorten trials in the future and save money.

HCPLive: Is there anything else from the EADV data you think is important to know?

Just that, interestingly, when you look at the clinical data, you saw large placebo responses, but when you looked at the biomarker data, you saw much smaller placebo responses. This is the amazing thing about biomarkers: they're objective, and for companies it's important to do this, because it can increase the delta between your drug and placebo and really get that differentiation.

HCPLive: Looking forward, what would you want to learn from phase 3 studies, and does the same biology apply to alopecia?

We also looked at pathways relevant to alopecia, and we saw they were modulated. I'm very excited about alopecia and this drug. I'd also like to learn what happens when you stop the drug after a year, or after prolonged use, and see when the disease actually comes back. Maybe it will take some time.

Editor's Note: This transcript has been edited for grammar and clarity using artificial intelligence tools.

Silverberg JI, Guttman-Yassky E, et al. REZOLVE-AD: 16-week induction results of rezpegaldesleukin in moderate-to-severe atopic dermatitis. Lancet. Published online August 25, 2026. doi:10.1016/S0140-6736(26)01143-8

Manson M, Manzo Margiotta F, Del Duca E, et al. Multi-omic profiling identifies early molecular responses to rezpegaldesleukin, a novel regulatory T cell-inducing therapy, in atopic dermatitis [abstract LB-219]. Presented at: EADV Congress 2026; September 30-October 3, 2026; Vienna, Austria.

Articles

Emma Guttman-Yassky, MD, discusses biomarker data showing rezpegaldesleukin's regulatory T-cell mechanism separates from placebo early.

Dermatology

The HCPLive dermatology page is a resource for medical news and expert insights on skin disease. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for dermatologic conditions, and more.

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Rezpegaldesleukin's Early Treg Signal in AD: Emma Guttman-Yassky, MD

Michelle O'Donoghue, MD, is the McGillycuddy-Logue Endowed Chair in Cardiology at Brigham and Women's Hospital and associate professor at Harvard Medical School

MAR001’s inhibition of ANGPTL4 substantially reduced fasting triglyceride (TG) levels in patients with 

 and remnant cholesterol (RC), according to new data from Part A of the TYDAL-TIMI 78 trial.

TYDAL-TIMI 78: MAR001 Reduces Fasting Triglyceride Through ANGPTL4 Inhibition

American Heart Association (AHA) Scientific Sessions 2026

 in Chicago, Illinois, by Michelle O’Donoghue, MD, the McGillycuddy-Logue Distinguished Chair in Cardiology at Brigham and Women’s Hospital, an associate professor of medicine at Harvard Medical School, and the senior investigator in the TIMI study group.

“We know that, with the growing prevalence of obesity, diabetes, and many other disease states that track along with having higher triglycerides, that the prevalence of hypertriglyceridemia is also growing for a variety of reasons,” O’Donoghue told 

 in an exclusive interview. “But it has been a tough nut to crack in terms of finding therapies that are both effective for lowering triglycerides and that lower risk of cardiovascular events.”

TYDAL-TIMI 78 is a 2-part phase 2b, randomized, double-blind, parallel-group, placebo-controlled study comparing MAR001 to placebo. Patients with elevated fasting or non-fasting TGs and RC, as well as a fasting LDL-C ≥50 mg/dL and ≤130 mg/dL, among other criteria, were eligible for enrollment in Part A of the trial. Patients with acute or chronic liver disease, a history of type 1 diabetes mellitus or diabetic ketoacidosis, or TG concentration ≥880 mg/dL, among other criteria, were excluded.

Enrolled patients were randomly assigned in a 1:1:1:1 ratio to receive either MAR001 300 mg, 450 mg, or 900 mg or matching placebo, administered subcutaneously over 24 weeks. The primary endpoint was percent change from baseline in fasting TG levels at week 12. Secondary endpoints included percent change in fasting RC at week 12, percentage of non-fasting TG at week 16, and the proportion of patients with baseline TG ≥150 mg/dL achieving TG <150 mg/dL at week 12, among others.

O’Donoghue and colleagues enrolled 236 patients in the trial, with 177 assigned to receive MAR001 and 59 to receive placebo. Of these patients, 235 received ≥1 dose and were included in the primary efficacy analyses. Mean age among all patients was 60.4 years, and the median TG level at baseline was 249.5 mg/dL (interquartile range [IQR], 210 to 313).

By week 12, the least-squares mean percent changes from baseline in fasting TG were -33.9% in the 300 mg arm, -35.7% in the 450 mg arm, and -40.3% in the 900 mg arm, compared with 5.2% in the placebo arm. The corresponding placebo-adjusted least-squares mean percent changes were -39.1 percentage points (95% CI, -46.8 to -31.5), -40.9 percentage points (95% CI, -48.7 to -33.1), and -45.5 percentage points (95% CI, -53.2 to -37.8), respectively (

 <.001 for all comparisons). Adverse events occurred in 123 of 177 (69%) patients in the pooled MAR001 group versus 45 of 58 (78%) patients in the placebo group.

O’Donoghue and colleagues concluded that inhibition of ANGPTL4 with MAR001 significantly reduced fasting TG levels, with the magnitude of lowering appearing more pronounced among patients with higher baseline levels. Additionally, treatment did not lead to adverse changes in aminotransferase levels or glucose homeostasis markers.

“So ultimately, some degree of effect modification was observed, and that has helped to set the stage for the phase B that is now launching for that program,” O’Donoghue said. “That is specifically looking at, and will be enrolling, patients who have severe forms of hypertriglyceridemia.”

Editors’ Note: O’Donoghue reports disclosures with Amgen, Eli Lilly, Janssen, Novartis, Novo Nordisk, Verve, and others.

O’Donoghue ML, Juliano RA, Yi BA, et al. ANGPTL4 inhibition in adults with elevated triglyceride levels. New England Journal of Medicine. Published online November 9, 2026. 

Marea Therapeutics. Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol (TYDAL-TIMI 78). ClinicalTrials.gov Identifier: NCT07028749. Updated September 2, 2026. Accessed November 10, 2026. 

https://clinicaltrials.gov/study/NCT07028749

Videos

Michelle O’Donoghue, MD, discusses the results of Part A of the TYDAL-TIMI 78 trial, demonstrating MAR001’s comparative efficacy to placebo.

Cardiology

Cardiology condition center page is a comprehensive resource for clinical news and insights on cardiovascular and cardiometabolic diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for heart disease and cardiovascular events, as well as associated diabetes, renal failure, and more...

Dyslipidemia

Conference

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Elafibranor normalized alkaline phosphatase (ALP) in 85.3% of patients with primary biliary cholangitis (PBC) and mildly elevated ALP despite ursodeoxycholic acid (UDCA), compared with 23.3% receiving placebo, according to late-breaking phase 3 ELSPIRE data presented by Kris Kowdley, MD, at 

“This entire population had a very good rate of response,” Kowdley, Director at Liver Institute Northwest, told 

Elafibranor Normalizes ALP in PBC:  ELSPIRE Trial Results

ELSPIRE: Elafibranor Normalizes ALP in PBC Below the 1.67 Threshold

Global PBC Study Group data show 10-year survival of 93.2% among patients with normal ALP, compared with 86.1% among those with ALP between 1 and 1.67 times the upper limit of normal (ULN).

 Yet patients in that range have generally been excluded from registrational trials. Elafibranor (Iqirvo), a peroxisome proliferator-activated receptor (PPAR)-α/δ agonist, was approved as second-line therapy based on the phase 3 ELATIVE trial, which enrolled patients with ALP of 1.67 times ULN or higher. In ELATIVE, 51% of patients receiving elafibranor achieved the composite biochemical response vs 4% receiving placebo, but only 15% normalized ALP.

ELSPIRE randomized 92 patients with ALP between 1 and 1.67 times ULN to elafibranor 80 mg or placebo.

 Response was consistent whether baseline ALP was 1.33 times ULN or lower (80.4% vs 26.1%) or higher (87.5% vs 14.3%), and 64.3% of patients receiving elafibranor achieved complete biochemical response vs 16.7% receiving placebo.

Adverse events were mostly mild or moderate, with no new safety signals.

 Kowdley notes slightly more fractures and weight gain with elafibranor, consistent with ELATIVE, and says the findings reinforce the need to monitor bone health in this population.

Watch the full interview to hear Kowdley explain why the treatment goal in PBC is shifting, how ELSPIRE compares with ELATIVE, and what the safety findings mean for counseling patients.

Murillo Perez CF, Harms MH, Lindor KD, et al; Global PBC Study Group. Goals of treatment for improved survival in primary biliary cholangitis: treatment target should be bilirubin within the normal range and normalization of alkaline phosphatase. 

. 2020;115(7):1066-1074. doi:10.14309/ajg.0000000000000557

Kowdley K, Lawitz E, Bowlus C, et al. Elafibranor to normalize alkaline phosphatase in patients with primary biliary cholangitis and incomplete response to ursodeoxycholic acid: results from the phase III randomized controlled ELSPIRE trial. Presented at: The Liver Meeting 2026; November 5-9, 2026; Denver, CO.

Kowdley KV, Bowlus CL, Levy C, et al. Efficacy and safety of elafibranor in primary biliary cholangitis. 

. 2024;390(9):795-805. doi:10.1056/NEJMoa2306185

Late-breaking ELSPIRE data show elafibranor normalized ALP in 85% of patients with PBC and ALP below 1.67 times ULN despite UDCA, vs 23% with placebo.

Hepatology

Cholangitis

cholangitis page, resources on the topics of medical news and expert insight into cholangitis can be found. Content includes articles, interviews, videos, podcasts, and breaking news on research, treatment, and drug development in PBC, PSC, and more!

Tim Smith joined the MJH Life Sciences team in 2022 and is currently an associate editor for 

. He is also the executive producer of two podcasts: 

. Previously, he was the producer of the Lungcast podcast. He graduated from UC Berkeley and worked in multimedia journalism as a staff writer prior to joining MJH. You can contact him at tsmith@mjhlifesciences.com.


It evaluated the efficacy and safety of risankizumab through 52 weeks in children and adolescents aged 6 to younger than 18 years with moderate to severe plaque psoriasis.

How did risankizumab compare with ustekinumab in adolescents?


At week 16, sPGA 0/1, PASI 75, and PASI 90 rates were similar in the 2 groups. PASI 100 was more frequent with risankizumab (41% vs 18%).

How is risankizumab dosed in pediatric patients in OptIMMize-1?


Dosing was weight based: 150 mg for patients weighing 40 kg or more and 55 mg for those under 40 kg, given subcutaneously at weeks 0 and 4 and then every 12 weeks.

Risankizumab produced durable gains in skin clearance, itch, and quality of life among children and adolescents with 

, according to 52-week results from the phase 3 OptIMMize-1 study published in the 

Risankizumab is an interleukin-23 (IL-23) p19 inhibitor and has been FDA approved for adults with moderate to severe psoriasis since 2019. Until now, no pediatric data had been reported.¹ The investigators said consensus guidance on advanced therapy for younger patients is still limited, and real-world biologic use in children trails the available evidence.¹

OptIMMize-1 (NCT04435600) enrolled 137 patients at 41 centers in 7 countries and had 4 parts.² Parts 1 and 2 enrolled adolescents aged 12 to younger than 18 years, and Parts 3 and 4 enrolled children aged 6 to younger than 12 years. Parts 1 and 3 were pharmacokinetic studies used to set weight-based dosing: 150 mg for patients weighing 40 kg or more and 55 mg for those under 40 kg.¹

How Did Risankizumab Compare with Ustekinumab in Adolescents with Psoriasis?

In Part 2, 82 adolescents were randomized 2:1 to assessor-blinded risankizumab (n = 54) or ustekinumab (n = 28). The analysis was descriptive, with no formal statistical comparisons.¹

At the 16-week mark, response rates were shown to be broadly similar between the 2 arms. A static Physician’s Global Assessment score of clear or almost clear (sPGA 0/1) was reached by 80% (43/54) of risankizumab recipients and 75% (21/28) of ustekinumab recipients. PASI 75 rates were 85% (46/54) and 86% (24/28), and PASI 90 rates were 65% (35/54) and 61% (17/28), respectively.¹

The arms separated more on complete clearance. PASI 100 was attained by 41% (22/54) of those in the risankizumab group compared with 18% (5/28) of the ustekinumab group. Most outcomes began improving as early as week 4.¹

Among 30 children treated in the open-label Part 4, week-16 rates were 90% (27/30) for sPGA 0/1, 87% (26/30) for PASI 75, 77% (23/30) for PASI 90, and 43% (13/30) for PASI 100. Responses were maintained or improved by week 52.¹

What Happened When Adolescents Stopped or Switched to Risankizumab?

Adolescents who responded at week 16 and stayed on risankizumab kept their skin clearance through week 52. Patients who had not responded initially, and those who switched from ustekinumab, continued to improve between weeks 16 and 52.¹

Of 21 responders re-randomized to treatment withdrawal, 8 (38%) lost response and entered a 16-week retreatment period, during which their skin clearance improved again. Itch scores followed a similar pattern. Children’s Dermatology Life Quality Index scores improved from baseline in every Part 2 treatment group.¹

Was Risankizumab Safe in Children and Adolescents with Psoriasis?

The authors reported risankizumab was well tolerated in all study parts, with a safety profile consistent with adult psoriasis trials. No adverse events led to discontinuation or death. There were no serious infections, cases of active tuberculosis, malignancies, or adjudicated anaphylactic reactions.¹

Part 2 had 2 serious events, both judged unrelated to treatment: a fibula fracture and a case of suicidal ideation in a patient with pre-existing depression. The most common adverse event was nasopharyngitis among adolescents in Part 2 (30%) and pyrexia among children in Part 4 (13%).¹

Antidrug antibody incidence was low and was not considered clinically relevant. The authors concluded the findings support risankizumab as a treatment option for moderate to severe psoriasis in pediatric patients.¹

Editor's Note: This summary has been edited for grammar and clarity using artificial intelligence tools.

Magnolo N, Wine Lee L, Reich A, et al. Efficacy and safety of risankizumab in paediatric patients with psoriasis in the OptIMMize-1 phase III study. 

. Published online September 26, 2026. doi:10.1093/bjd/ljag403.

ClinicalTrials.gov. A study of subcutaneous risankizumab injection for pediatric participants with moderate to severe plaque psoriasis to assess change in disease symptoms. NCT04435600. Accessed November 10, 2026. 

https://clinicaltrials.gov/study/NCT04435600

Risankizumab improved skin clearance, itch, and quality of life through 52 weeks in pediatric psoriasis in the phase 3 OptIMMize-1 study.

Plaque Psoriasis

The HCPLive plaque psoriasis page is a resource for medical news and expert insights on psoriasis. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for psoriatic disease, and more.

OptIMMize-1: Risankizumab Clears Skin in Children, Teens with Psoriasis

David Singh, MBBChir, MA (Cantab), MRCP, MD, FBPhS, FERS, is a professor of Clinical Pharmacology & Respiratory Medicine at the University of Manchester and is the medical director of the Medicines Evaluation Unit (MEU).

Targeting the alarmin interleukin (IL)-33 may extend biologic therapy to patients with 

chronic obstructive pulmonary disease (COPD)

 who lack evidence of type 2 inflammation, according to Dave Singh, MD. Singh is professor of clinical pharmacology and respiratory medicine at the University of Manchester, medical director of the Medicines Evaluation Unit and a member of the GOLD Science Committee. He discussed IL-33 inhibition and the 2027 GOLD report with 

IL-33 Biologics and the 2027 GOLD Report, With Dave Singh, MD

What Did OBERON and TITANIA Show for IL-33 Inhibition?

Singh described non-type 2 COPD, marked by low eosinophil counts, as an area of clear unmet need. IL-33 is released by epithelial and endothelial cells and drives a broad range of inflammatory pathways, which makes it a candidate target beyond eosinophilic disease.

In the replicate phase 3 OBERON and TITANIA trials, tozorakimab 300 mg every 4 weeks reduced moderate to severe exacerbations by 30% and 29%, respectively, across former and current smokers.¹˒² In a pooled analysis, the reduction was 23% among patients with blood eosinophil counts below 150 cells/µL and 43% among those with counts of 300 cells/µL or higher.²

Singh expects responses to vary among patients. Until clinicians can predict who will benefit, he said, treatment decisions may depend on assessing response after a trial of therapy.

How Does the 2027 GOLD Report Refine COPD Guidance?

Singh described the 2027 GOLD update as a refinement rather than a major advance, adding detail on issues clinicians see often in practice.³ The report expands its discussion of the evidence on mucus plugging. It also adjusts the language around early, mild and pre-COPD, terms Singh acknowledged often cause confusion.

He linked the focus on earlier disease to clinical trial design. Most COPD trials enroll patients late in the course of the disease. Singh emphasized the value of studying younger, higher-risk individuals before substantial lung damage develops, both to support earlier diagnosis and to build a stronger evidence base.

Why Are Unlicensed Biologics Left Out of the GOLD Algorithm?

GOLD discusses published trial data for investigational biologics such as tozorakimab and astegolimab but leaves them out of its treatment algorithm until they are licensed.³ Singh noted that tozorakimab has 2 positive phase 3 trials. Roche has reported that astegolimab’s phase 3 results were less consistent.⁴

He advised clinicians to follow their local licensing framework. Once a biologic is approved in a given country, clinicians there can prescribe it according to its label.

Editor’s Note: This summary of a session has been edited for grammar and clarity using artificial intelligence tools. Singh had no relevant financial disclosures of note.

Sciurba FC, Watz H, Bourdin A, et al. Tozorakimab to prevent COPD exacerbations. 

. Published online September 8, 2026. doi:10.1056/NEJMoa2606998.

Indian Pharma Post. AstraZeneca’s tozorakimab cuts COPD exacerbations by up to 34% in broad phase III population. Published September 11, 2026. Accessed November 10, 2026. 

https://www.indianpharmapost.com/news/astrazenecas-tozorakimab-cuts-copd-exacerbations-by-up-to-34-in-broad-phase-iii-population-21787

Agustí A, Vogelmeier CF. 2027 GOLD report and review. Presented at: GOLD 2026 COPD International Conference; November 5-6, 2026; Philadelphia, PA.

Roche. Roche provides update on astegolimab in chronic obstructive pulmonary disease. Published July 21, 2025. Accessed November 10, 2026. 

https://www.roche.com/media/releases/med-cor-2025-07-21

Dave Singh, MD, discusses IL-33 inhibition for non-type 2 COPD, 2027 GOLD report refinements, and how to view biologics not yet in the GOLD algorithm.

COPD

COPD condition center page, resources on the topics of medical news and expert insight into chronic obstructive pulmonary disease can be found. Content includes articles, interviews, videos, podcasts, and breaking news on COPD research, treatment, and drug development.

In 3-year BE HEARD data, close to half of bimekizumab-treated HS patients reported no quality-of-life impact, regardless of baseline draining tunnel count.

Hidradenitis Suppurativa

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3-Year BE HEARD Data Link Bimekizumab to Fewer HS Draining Tunnels

Autumn Burnette, MD, FACAAI, a clinical allergist physician at Howard University.

Podcasts

Autumn Burnette, MD, hosts a new monthly allergy and immunology podcast from HCPLive, opening with an episode on hereditary angioedema.

podcasts page features a feed of medical news and interview podcast series, including DocTalk, Lungcast, Derm Discussions, and Heart Trials.

Allergy

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Allergy Rounds With Dr. Autumn

Allergy Rounds is a monthly podcast where Autumn Burnette, MD, of Howard University makes the rounds with allergists, pulmonologists, dermatologists, and other specialists to discuss what’s new, from emerging HAE therapies and gene-editing research to newly approved triple therapies and the payer battles that stand between patients and treatment. Each episode goes past the press release to ask what a new approval, trial result, or guideline shift actually means for the clinician deciding what to prescribe next week.

Martina J. Porter, MD, is a dermatologist at Beth Israel Deaconess Medical Center.

Martina Porter, MD, of Beth Israel Deaconess Medical Center discusses unmet needs in HS and where oral povorcitinib fits among emerging options.

Rheumatology Winter Clinical Symposium

Unmet Needs in HS and Emerging Oral Options, With Martina Porter, MD

Scientific Affairs, Innovation, and New Technology

MAESTRO-NASH data show early liver fat reductions on MRI-PDFF predict biopsy-confirmed MASH resolution and fibrosis improvement with resmetirom.

MASH / MASLD

The HCPLive MASH & MASLD page is a comprehensive resource for clinical news and insights on metabolic dysfunction-associated steatotic liver disease and steatohepatitis. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for fatty liver disease, steatohepatitis, and more.

Early Liver Fat Changes Predict Resmetirom Response in MASH

Mazen Noureddin, MD, MHSc, is a professor of medicine and a transplant hepatologist at Houston Methodist and director of the Houston Research Institute.

Phase 2 data show zabopegdutide, a dual GLP-1/glucagon agonist, improved fibrosis and drove MASH resolution vs placebo at 48 weeks.

Zabopegdutide Improves Fibrosis, MASH Resolution at 48 Weeks

Physician and CEO, Chicago Allergy Center, and board director at American Lung Association

Juanita Mora, MD, of Chicago Allergy Center discusses strategies from boosters and antiviral prophylaxis to specialist counseling.

Pulmonology

Infectious Disease condition center page is a comprehensive resource for clinical news and insights on respiratory health. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for asthma, COPD, interstitial lung disease, COVID-19, and more.

Strategic Alliance Partnership

Closing the COVID-19 Prevention Gap This Flu Season, With Juanita Mora, MD

Stay updated with the latest healthcare breakthroughs, including 96-week durability data for GSK’s bepirovirsen in hepatitis B, and more.

Endocrinology

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This page also hosts content previously published by EndocrinologyNetwork. 


The HCPFive: Top News for Healthcare Providers from the Week of 11/1

Ryan Livingston joined the MJH Life Sciences team in March of 2025, shortly after graduating from TCNJ with a bachelor’s degree in English. He enjoys creative writing, reading, and scuba diving. He can be reached at rlivingston@mjhlifesciences.com.

The FDA approved asundexian with antiplatelet therapy after noncardioembolic ischemic stroke or high-risk TIA, based on OCEANIC-STROKE data.

Stroke

On the HCPLive stroke page, resources on the topics of medical news and expert insight into CVA can be found. Content includes articles, interviews, videos, podcasts, and breaking news on stroke medicine, and more.

FDA News

Asundexian Receives FDA Approval for Secondary Stroke Prevention

Robert S. Rosenson, MD is a professor of cardiology at the Icahn School of Medicine at Mount Sinai.

Robert Rosenson, MD, discusses the long-term extension of the phase 3 PALISADE trial, which demonstrated plozasiran’s association with lower ApoC3 and fasting TG.

PALISADE Extension Supports Plozasiran’s Efficacy, Safety in Familial Chylomicronemia

Most patients with type 2 COPD also have non-type 2 inflammation, shaping how clinicians may use targeted and anti-alarmin biologics, per Dave Singh, MD.

Latest News

Rezpegaldesleukin's Early Treg Signal in AD: Emma Guttman-Yassky, MD

TYDAL-TIMI 78: MAR001 Reduces Fasting Triglyceride Through ANGPTL4 Inhibition

ELSPIRE: Elafibranor Normalizes ALP in PBC Below the 1.67 Threshold

OptIMMize-1: Risankizumab Clears Skin in Children, Teens with Psoriasis

IL-33 Biologics and the 2027 GOLD Report, With Dave Singh, MD