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Disease Progression and Extrahepatic Manifestations of PBC

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What are some major complications and comorbidities associated with PBC (eg, vitamin deficiency, osteoporosis, comorbid conditions such as MASH, autoimmune conditions, obesity)?

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Video Series

Expanding Treatment Options for Primary Biliary Cholangitis with Novel Therapies

Primary biliary cholangitis (PBC) is associated with several complications and comorbidities. Vitamin deficiencies, particularly fat-soluble vitamins like A, D, E, and K, are common due to malabsorption. Osteoporosis is a significant concern, often resulting from chronic cholestasis and vitamin D deficiency. Metabolic-associated steatohepatitis (MASH) can co-occur, complicating liver health further. Autoimmune conditions, such as Sjögren's syndrome and thyroid disorders, frequently accompany PBC. Obesity exacerbates liver disease progression and complicates management. These factors necessitate comprehensive monitoring and management strategies to mitigate their impact on patient outcomes.

The panel of experts examine major complications and comorbidities associated with primary biliary cholangitis (PBC), including vitamin deficiencies, osteoporosis, and conditions like metabolic-associated steatohepatitis (MASH), autoimmune disorders, and obesity.