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Integration of PPAR Agonists in Treatment Landscape of PBC

Video content above is prompted by the following:

How do you envision the uptake and integration of PPAR agonists into the current treatment landscape for PBC? What would you recommend for someone who is taking a fibrate for PBC?

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Video Series

Expanding Treatment Options for Primary Biliary Cholangitis with Novel Therapies

Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by the progressive destruction of small and medium-sized bile ducts within the liver. This destruction is primarily mediated by autoreactive T lymphocytes targeting the epithelial cells of the bile ducts. The ensuing cholestasis leads to the accumulation of toxic bile acids, causing hepatocellular damage and inflammation. Over time, this chronic inflammatory process results in fibrosis and eventually cirrhosis. The pathophysiology of PBC is influenced by genetic predispositions and environmental factors, contributing to its complex etiology and progression.

The panel of experts explore the potential integration of peroxisome proliferator-activated receptor (PPAR) agonists into the current treatment landscape for primary biliary cholangitis (PBC) and provides recommendations for patients currently taking fibrates for managing the disease.