Exploring the Role of Oral JAK Inhibitors in Atopic Dermatitis - Episode 1

The Role of the JAK/STAT Signaling Pathway in Atopic Dermatitis

Published on: March 21, 2025

Linda Stein Gold, MD, Lisa Swanson, MD, PhD, James Song, MD, Christopher G. Bunick, MD, PhD

Experts discuss the JAK/STAT signaling pathway’s critical role in immune response, highlighting the involvement of JAK enzymes in atopic dermatitis (AD) pathogenesis and how JAK inhibitors effectively reduce itch and inflammation, improving symptoms and skin clearance in AD.

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EP. 1: The Role of the JAK/STAT Signaling Pathway in Atopic Dermatitis

EP. 2: JAK1 Selective Inhibition and the Impact of Selectivity on Efficacy and Safety

Video content above is prompted by the following:

Briefly describe the JAK/STAT signaling pathway and its role within the immune system.
Which JAK enzymes are involved in the pathogenesis of AD?
How does the JAK/STAT pathway play a role in itch and inflammation?
How do JAK inhibitors specifically work to improve AD symptoms (such as itch) and skin clearance?