Turning the Tide: Early PCSK9 Intervention Post-ACS - Episode 1
The Cumulative Burden of Lipoprotein Cholesterol (LDL-C)
Panelists discuss how lowering low-density lipoprotein cholesterol (LDL-C) levels remains a central strategy for preventing atherosclerotic cardiovascular disease (ASCVD), emphasizing the importance of managing cholesterol years to reduce long-term cardiovascular risk.
Summary for Physicians:
Lowering LDL-C levels continues to be the central strategy for both primary and secondary prevention of ASCVD, as emphasized across all major clinical guidelines. Elevated LDL-C levels contribute significantly to the development and progression of ASCVD, and reducing LDL-C levels is proven to decrease the risk of cardiovascular events.
Cumulative Burden of LDL-C (Cholesterol Years) and ASCVD Risk:
The concept of cholesterol years refers to the cumulative exposure of the arteries to elevated levels of LDL-C over time. This accumulation of high cholesterol levels increases the lifetime risk of ASCVD. The longer an individual has elevated LDL-C levels, the greater the total burden on their vascular system, which may accelerate the development of atherosclerotic plaques and increase the likelihood of adverse cardiovascular outcomes. This concept underscores the importance of early and sustained management of LDL-C levels to reduce long-term ASCVD risk. Managing LDL-C levels effectively over the years can help minimize this cumulative burden, especially for individuals at higher genetic or environmental risk.
In clinical practice, focusing on early intervention and long-term LDL-C control can play a pivotal role in reducing both primary and secondary ASCVD events.
