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Switching from Biologics to JAK Inhibitors in Atopic Dermatitis: Clinical Data

Video content above is prompted by the following:

Can you discuss disease control with abrocitinib or upadacitinib in patients previously treated with dupilumab?

When would you switch a patient to a JAK inhibitor?

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Atopic Dermatitis

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Atopic Dermatitis condition center page, resources on the topics of medical news and expert insight into eczema can be found. Content includes articles, interviews, videos, podcasts, and breaking news on dermatitis research, treatment, and drug development.

Advances in Oral Systemic Treatments for Management of Atopic Dermatitis

Abrocitinib and upadacitinib, both JAK inhibitors, have shown efficacy in disease control for patients previously treated with dupilumab. These agents offer an alternative mechanism of action, potentially benefiting patients who have not achieved optimal results with dupilumab. Switching to a JAK inhibitor may be considered when a patient experiences inadequate response, loss of efficacy, or adverse effects with dupilumab. The decision to switch should be individualized, taking into account the patient's disease severity, treatment history, and risk factors associated with JAK inhibitors.

Medical experts discuss disease control with abrocitinib or upadacitinib in patients previously taking dupilumab and explain the circumstances under which they would switch a patient to a JAK inhibitor.