Panelists discuss how biologic therapy management requires strategic monitoring with initial assessment at 4 to 12 weeks, defining nonresponse at 12 to 16 weeks, addressing adherence before considering alternatives such as switching biologics with different mechanisms or transitioning to JAK inhibitors based on comorbidities, coverage, administration preferences, and safety considerations—emphasizing that the expanding therapeutic landscape enables personalized approaches that have transformed expectations for moderate to severe atopic dermatitis.