Chronic Spontaneous Urticaria and Bruton Tyrosine Kinase: A Multispecialty Expert Discussion - Episode 2

Pathophysiology of Chronic Spontaneous Urticaria

Published on: February 13, 2025

Giselle Mosnaim, MD, MS , Shyam Joshi, MD , Mark Lebwohl, MD, Jason Hawkes, MD, MS

Panelists discuss how chronic spontaneous urticaria develops through 2 distinct pathways: autoallergic CSU involving IgE-mediated mast cell activation (type I hypersensitivity) and autoimmune CSU where IgG autoantibodies target FcεRI receptors or IgE itself (type IIb hypersensitivity), both ultimately leading to mast cell degranulation and wheal formation.

EP. 1: Chronic Spontaneous Urticaria and Bruton Tyrosine Kinase: A Multispecialty Expert Discussion

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EP. 2: Pathophysiology of Chronic Spontaneous Urticaria

EP. 3: Current CSU Treatment Approach and the Role of Bruton Tyrosine Kinase

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Describe the pathogenesis of chronic spontaneous urticaria (CSU), including the IgE (autoallergic; type I) and IgG (autoimmune; type IIb) CSU subtypes.