Panelists discuss how ensifentrine is a nebulized inhaled therapy, a small molecule inhibitor of PDE3 and PDE4, and is compelling because there are very few adverse effects. There are also compelling results from studies that show bronchial dilatation and exacerbation reduction.
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The most impactful changes to the 2025 GOLD Report pertain to chronic obstructive pulmonary disease (COPD) management, specifically the addition of 2 new treatment options, ensifentrine and dupilumab, that were approved for use by the FDA in June 2024 and September 2024, respectively.
What is ensifentrine (first-in-class PDE3 and PDE4 inhibitor), and how do its effects translate for the management of stable COPD?