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Endothelin Pathway

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There are numerous factors that contribute to the pathophysiology of hypertension. One is the endothelin pathway, which plays a crucial role in regulating vascular tone, blood pressure, and vascular remodeling via vasodilators (eg, nitric oxide) and vasoconstrictors (eg, endothelin-1).

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Hypertension

The HCPLive hypertension page is a resource for medical news and expert insights on high blood pressure. This page features expert-led coverage, articles, videos and research on the therapies and development of treatments for hypertension, and more.

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Video Series

Advancing Hypertension Management: Unmet Needs, Endothelial Dysfunction, and CKD Therapies

Difficult-to-treat hypertension is a condition where blood pressure remains uncontrolled despite the use of three or more antihypertensive medications, including a diuretic. This condition is distinct from resistant hypertension, which is more common and involves blood pressure that is not controlled with three medications but may not include a diuretic. Difficult-to-treat hypertension is less frequent, affecting a smaller subset of patients with high blood pressure. It often requires a more comprehensive approach, including lifestyle modifications and potential secondary causes evaluation, to achieve optimal management.

Panelists discuss how the endothelin pathway critically regulates blood pressure and vascular health through the interplay between vasodilators and vasoconstrictors such as endothelin-1, representing a key mechanism in hypertension pathophysiology.