Embracing New Therapies in Schizophrenia Management - Episode 1
In part 1 of 5, panel moderator gives an overview of the Special Report focusing on the approval of Xanomeline and tropism chloride capsules for schizophrenia.
On September 26, 2024, the US Food and Drug Administration (FDA) approved xanomeline and tropism chloride capsules (Cobenfy), backed by evidence in phase 3 EMERGENT trials. The approval marks the start of a new era in the management of schizophrenia, as the agent, formerly known as KarXT, marks the first new pharmacological approach to treating schizophrenia since the 1970s.
Xanomeline and tropism chloride capsules act as a dual M1/M4 muscarinic acetylcholine receptor agonist in the central nervous system. Unlike previous schizophrenia treatments, this drug does not directly regulate the dopamine receptor—only indirectly modulates.
To commemorate and offer perspective on what this approval means for the healthcare community, HCPLive Psychiatry hosted a Special Report where leading subject matter experts discussed the approval of xanomeline and tropism chloride capsule for schizophrenia. In this opening segment, moderator Sam Clark, MD, PhD, introduces panelists Rishi Kakar, MD, lead investigator of the EMERGENT trials, and Andrew J. Cutler, MD. The remainder of this panel discussion, which can be found below, focused not only on the approval of xanomeline and tropism chloride capsules but also on the latest updates and the most pressing unmet needs in schizophrenia management.
Relevant disclosures for Cutler include Karuna, Bristol Myers Squibb, and others. Relevant disclosures for Kakar include Karuna, Bristol Myers Squibb, and others. Relevant disclosures for Clark include Terran Biosciences.