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An infectious disease specialist discusses the differences in binding affinity between dolutegravir and bictegravir and how it informs treatment selection.

Differences in Binding Affinity Between Integrase Inhibitors in HIV

Video content above is prompted by the following questions:

Integrase inhibitors like dolutegravir and bictegravir bind to the active site of the integrase and as such suppress the HIV virus; they are integral to modern therapeutic algorithms.

Can you explain the differences in binding affinity between dolutegravir and bictegravir and does this impact your treatment selection?


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