Brian Lipworth, MD

Lipworth shared findings from 2 studies that he presented data from at the AAAAI/WAO Joint Congress.

Oscillometry Validates Airway Function Improvements With Dupilumab, with Brian Lipworth, MD

A new analysis of secondary endpoints in the phase 4 VESTIGE study (NCT04400318) found that dupilumab improved small airway dysfunction (SAD) in people with type 2 high moderate-to-severe asthma, possibly explaining improvements in disease control.

These findings were presented at the 2025 American Academy of Allergy, Asthma, and Immunology (AAAAI)/World Allergy Organization (WAO) Joint Congress, February 28-March 3, in San Diego, California, by Brian Lipworth, MD, Professor of Allergy and Pulmonology at University of Dundee.

 spoke with Lipworth to learn more about what was seen with dupilumab’s effect on SAD in both the VESTIGE study and another study from University of Dundee he presented on.

He shared how the data further validate dupilumab’s use for improving airway function via 3 mechanisms targeting airway smooth muscle, endobronchial inflammation and mucus plug dissolution.

“I think that's why it's probably the gold standard biologic, in my humble opinion, for improving small airway function. That's important because conventionally, inhalers that we use in asthma don't really adequately reach the small airways, and I think that's the reason why that biologics, particularly dupilumab, are so effective, because… they can reach all of the airways with an injectable systemic biologic, which you can't reach with an inhaled drug,” Lipworth said.

Lipworth also discussed further questions that he would like to see answered with dupilumab by using oscillometry, including potential effects in chronic obstructive pulmonary disease (COPD).

Lipworth B, Saralaya D, Zhang M, et al. Dupilumab Produces Clinically Relevant Improvement in Small Airway Dysfunction in Patients With Moderate-to-Severe Asthma: Results From the Phase 4 VESTIGE Study. Presented at: AAAAI/WAO Joint Congress, San Diego; 2/28-3/3. Abstract 936.

Lipworth B, Stewart K, Kuo C, Greig R, Chan R. Evaluation of Small Airways Dysfunction with Dupilumab using Airway Oscillometry in Uncontrolled Severe Asthma. Presented at: AAAAI/WAO Joint Congress, San Diego; 2/28-3/3. Abstract 057.

Brian Lipworth, MD

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